A modelling approach to explain mutually exclusive and co - occurring genetic alterations in bladder tumorigenesis
نویسندگان
چکیده
Elisabeth Remy, Sandra Rebouissou, Claudine Chaouiya, Andrei Zinovyev, François Radvanyi, Laurence Calzone 1. Aix Marseille Université, CNRS, Centrale Marseille, I2M, UMR 7373, 13453 Marseille, France 2. Institut Curie, PSL Research University, 75248 cedex 05 Paris, France 3. CNRS, UMR 144, Oncologie Moléculaire, Equipe Labellisée Ligue Contre le Cancer, Institut Curie, 75248 cedex 05 Paris, France 4. INSERM, UMR-1162, Génomique Fonctionnelle des Tumeurs Solides, IUH, 75010 Paris, France, present address 5. Instituto Gulbenkian de Ciência, Oeiras, Portugal. 6. INSERM, U900, 75248 cedex 05 Paris, France 7. Ecole des Mines ParisTech, 77305 cedex Fontainebleau, France * equal contribution † corresponding author
منابع مشابه
Integrated Systems and Technologies: Mathematical Oncology A Modeling Approach to Explain Mutually Exclusive and Co-Occurring Genetic Alterations in Bladder Tumorigenesis
Relationships between genetic alterations, such as co-occurrence or mutual exclusivity, are often observed in cancer, where their understanding may provide new insights into etiology and clinical management. In this study, we combined statistical analyses and computational modeling to explain patterns of genetic alterations seen in 178 patients with bladder tumors (either muscle-invasive or non...
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Relationships between genetic alterations, such as co-occurrence or mutual exclusivity, are often observed in cancer, where their understanding may provide new insights into etiology and clinical management. In this study, we combined statistical analyses and computational modeling to explain patterns of genetic alterations seen in 178 patients with bladder tumors (either muscle-invasive or non...
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